Orlistat is a medicine that promotes loss of weight by preventing the absorption of fat in food. In the intestine, an enzyme called lipase which produced primarily by the pancreas breaks apart fat in food so that it can be absorbed into the body. Orlistat blocks the action of lipase and thereby prevents from breaking apart and absorption of fat. Orlistat blocks absorption of about one-fourth of the fat in a meal. The unabsorbed fat is excreted in the bowel movement. Orlistat has approved by the FDA by prescription in 1999.

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